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Patients on metformin HCl at a dosage of at least 1,500 mg/day were randomized following a 2-week placebo lead-in period to glipizide or dapagliflozin (5 mg or 2.5 mg, respectively) and were uptitrated over 18 weeks to optimal glycemic effect (FPG 300 mg/g)
This delay is particularly critical for patients with advanced maternal age (AMA) or diminished ovarian reserve (DOR), for whom any postponement may result in an irreversible decline in reproductive potential
Ther Adv Reprod Health
J Pineal Res 71(2):e12750
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